We referenced the transcriptomes of the cells in this region and determined that aside from tumor cells, the major immune cells in this section were dendritic cells (DCs; Itgax/ Cd11c) (Supplemental Fig. 12b) and CD8+ T cells (Fig. 4e), both of which are immune populations influenced by Type I IFNs (13). This evidence concerns the gene ITGAX and neoplasm.