BRCA1 and ovarian cancer: The results from <i>BRCA1</i> variants tested in this assay are a resource for clinical geneticists for evidence to evaluate VUS in <i>BRCA1</i> .<h4>Author summary</h4>Most missense substitutions in <i>BRCA1</i> are variants of unknown significance (VUS), and individuals with a VUS in <i>BRCA1</i> cannot know from genetic information alone whether this variant predisposes to breast or ovarian cancer.