Study has shown that glycosylation of CD147 plays significant roles in pathological cardiac hypertension and fibrosis, that overexpression of well glycosylated HG but not none-glycosylated CD147 mutant could increase cardiac fibrosis, exacerbate cardiac hypertension, and aggravate myocardial oxidative stress and ferroptosis58.To find novel therapeutic agents for COVID-19 therapy, we then tested the effect of niclosamide on CD147 based on our newly uncovered HuR-CD147 regulation mechanism. This evidence concerns the gene BSG and COVID-19.