Among these drugs, pharmacological inhibitors of the receptor-interacting serine/threonine protein kinase 1 (RIPK1) have entered clinical trials for the treatment of autoimmune diseases (psoriasis, ulcerative colitis and rheumatoid arthritis), as well as some cancers and neurological disorders (Mifflin et al., 2020). The gene discussed is RIPK1; the disease is ulcerative colitis.