These results suggest that the RH_Score is closely related to HBM pathological types, and a high RH_ score may be involved in a poor prognosis by activating the MAPK signaling pathway, WNT signaling pathway, mTOR signaling pathway, Notch signaling pathway, P53 signaling pathway, cell cycle and TGF‐β signaling pathway and other signaling pathways mediating tumor progression. This evidence concerns the gene TGFB1 and neoplasm.