At the same time, mutation of S198E, the phosphorylation site of SEPT12, in the human protein (corresponding to S196E of SEPT12 in mouse) resulted in loss of sperm motility as well as the complete disappearance of the annulus/septin ring, ultimately leading to male infertility (Shen et al., 2017). The gene discussed is SEPTIN12; the disease is male infertility.