In the present study, we used the TCGA and GTEx databases to analyze SREBF1 expression in human pan-cancer and found that SREBF1 was significantly upregulated in 12 cancers, including BLCA, BRCA, DLBC, ESCA, HNSC, KICH, KIRC, KIRP, LGG, PAAD, STAD, and THYM. Here, SREBF1 is linked to cancer.