Fouzder et al. [49] demonstrated that kaempferol diminished Nrf2 at mRNA and protein levels in nonsmall cell lung cancer cells, leading to the downregulation of Nrf2 downstream genes, including GST, AKR1C1, HO1, and NQO1, resulting in cancer cells sensitive to apoptosis. The gene discussed is AKR1C1; the disease is cancer.