HSP90 may also contribute to the development of pulmonary fibrosis through IL-6, as HSP90 mediates activation of the nuclear factor kappa light chain enhancer in the B cell (NF-κB) dependent inflammatory pathway, promoting IL-6 production (Bohonowych et al., 2014; Bellaye et al., 2018). Here, NFKB1 is linked to pulmonary fibrosis.