Cytokines: IL-6, IL-8, BAFF, et al. ↑ Neys et al. (2021), Roman and Chiba (2021). Activating JUK, p38 MAPK, and mTOR pathways Roman and Chiba 2021. Autoantibodies produced are closely associated with ILD Lee et al. (2013), including anti-citcitline protein antibody (ACPA), rheumatoid factor (RF), Sjogren’s syndrome-associated antigen A antibody, anti-synthetase antibody or anti-melanoma differentiation-associated protein 5 antibody, anti-topoisomerase I antibody, Anti-U11/U12 ribonucleoprotein antibodies and anti-eukaryotic initiation factor 2B antibodies and so on. This evidence concerns the gene RNU12-2P and interstitial lung disease.