Baek et al. (2017) demonstrated that 27-HC increases the number and activity of polymorphonuclear neutrophils (PMN) and γδT cells, and reduces the cytotoxic CD8+ T cell population. In addition, oxysterol promotes tumor growth by inhibiting dendritic cell (DC) migration to lymphoid and by promoting the recruitment of protumor neutrophils in the tumor microenvironment (Raccosta et al., 2013). Here, CD8A is linked to neoplasm.