In addition, using TAK-475, a potent inhibitor of squalene synthase (Fdft1), researcher evaluated the efficacy and tolerability of TAK-475 in a mouse transplant model of pancreatic ductal adenocarcinoma (PDA) and showed significantly reduced tumor growth (Biancur et al., 2021). Here, FDFT1 is linked to pancreatic ductal adenocarcinoma.