SQLE and liver cancer: Mahoney et al. (2019) demonstrated that small cell lung cancer (SCLC) lines display sensitivity to NB-598, a known inhibitor of squalene epoxidase (SQLE). In addition, terbinafine (TB) is an antifungal agent that inhibits squalene epoxidase and has been shown to inhibit tumor growth and angiogenesis (Chien et al., 2012), by the mechanism that TB suppresses in vitro and in vivo proliferation of various tumor cells, including oral, colon and liver cancer via inhibiting DNA synthesis and activating apoptosis, which is related to the p53-dependent signaling pathway (Lee et al., 2003).