In our study, mRNA expression of SIRT 1 in hepatic tissues was found upregulated in HFD/STZ–exposed rats, while treatment showed is downregulation, hence supporting its protective potential against high fat diet-induced hepatic steatosis (Li et al., 2011), insulin sensitivity and oxidative stress possibly mediated through AKT pathway. This evidence concerns the gene AKT1 and Hepatic steatosis.