Administration of high fat diet for 56 days along with streptozotocin develop glucose intolerance, insulin resistance, β-cell destruction, alterations in inflammatory biomarkers (TNF-α, IL-6), adipocytokines (leptin, chemerin and adiponectin) levels, oxidative stress biomarkers (CAT,SOD and MDA) and diabetic candidate genes like IRS-1. The gene discussed is TNF; the disease is Insulin resistance.