The slowdown of cell cycle relates to cellular senescence closely, and the Skp2 inhibition induces the senescence of endothelial progenitor cell (EPC) (Wang H. H. et al., 2020), and inhibits angiogenic senescence, leading to aging-related vasculopathy, which finally affects atherosclerosis related disease or vascular event. This evidence concerns the gene SKP2 and vascular disorder.