Comprehensively considering the characteristics of Skp2 protein, such as the self-amplifying feedback loop of itself and potentially side effects of Skp2 inhibition (Yung et al., 2007), it could be suggested to adopt two or more Skp2-inhibiting compounds for Skp2 inhibitory treatment clinically, which would be a better way in tumor treatment than single Skp2 inhibitors. The gene discussed is SKP2; the disease is neoplasm.