SKP2 and small cell lung carcinoma: Furthermore, MLN4924 has been reported to cause cell death in small-cell lung cancer organoids, and a significant increase in Skp2 protein levels upon MLN4924 treatment has also been reported, resulting from the inhibited assembling of SCFSkp2 complex by MLN4924, in the case the Skp2 protein is not part of SCFSkp2 E3 ligase (Zhao et al., 2020).