Treatment with curcumin inhibited Skp2 mRNA expression, increased p21 and p27 protein levels, inhibited cell proliferation, and induced cell apoptosis in several tumors, such as human head and neck squamous cell carcinoma cell lines(Khan et al., 2018), lung cancer cell line H460 (Chiang et al., 2015), breast cancer cell line MDA-MB-231 (Jia et al., 2014), human glioma cell line U251 and SNB19 (Wang et al., 2015) (Table 2), human nasopharyngeal carcinoma cell lines CNE1 and CNE2 (Feng et al., 2017), and pancreatic cancer cell lines Patu8988 and Panc-1 (Su et al., 2016b) (Table 2). This evidence concerns the gene SKP2 and breast cancer.