Accordingly, treatment of azaindole in human colon carcinoma cell line HCT116 has been found to decrease Skp2 protein levels in a dose-dependent manner and inhibit cell proliferation in CellTiter-Glo assays, along with the phenomenon of deneddylation inhibition demonstrated by trapping of Cul1 in the neddylated status, supporting that azaindoles are Skp2 inhibitory compound, which induced autoubiquitination and degradation of Skp2 (Altmann et al., 2017) (Table 2). Here, SKP2 is linked to colon carcinoma.