However, besides cancers, Skp2 was also reported to associate with other non-cancer diseases, such as chronic kidney disease (Suzuki et al., 2011), pulmonary Fibrosis(Li et al., 2016; Mikamo et al., 2018), systemic dysregulation of COVID-19 patients(Gassen et al., 2021), and asthma(Park et al., 2016; Liu B. et al., 2021) as well. This evidence concerns the gene SKP2 and cancer.