To the contrary, in NSCLC cell line H460, SZL-P1-41(5.15 μM) exerted stronger inhibitory effects than SKPin C1(33 μM) (Zhao et al., 2020), indicating that in lung cancer with same mechanisms of H460, disrupting the SCFSkp2 complex prevented tumor development more significantly than only preventing p27 degradation. The gene discussed is CDKN1B; the disease is lung cancer.