SKP2 and non-small cell lung carcinoma: It has been demonstrated to bind to Skp2 by forming H-bonds with the Lys145 residue, decreasing Skp2 stability, preventing Skp1-Skp2 interaction and thus inhibiting SCFSkp2 E3 ligase, leading to decreased tumor proliferation and migration in non-small-cell lung cancer (He et al., 2021).