SKPin C1 has also been reported to inhibit uveal melanoma and lung cancer growth both in vitro and in vivo (Zhao et al., 2020) (Zhao et al., 2019) (Table 2); trigger cell apoptosis in metastatic melanoma and breast cancer in vitro; and inhibit proliferation of murine primary T-ALL cells with wildtype Skp2, as well as several human T-ALL cell lines (Rodriguez et al., 2020) (Table 2). This evidence concerns the gene SKP2 and metastatic melanoma.