SKP2 and neoplasm: Since been reported to regulate cell cycle, promoting cell proliferation via p27 (Carrano et al., 1999), Skp2 was discovered to have various other functions in tumor pathological processes, including apoptosis (Nakayama et al., 2000), DNA repair (Wu J. et al., 2012), tumor metastasis (Li et al., 2004), and senescence (Lin et al., 2010; Wang et al., 2012).