SKP2 and breast cancer: However, in breast cancer cell lines MCF-7 and MDA-MB-231, pancreatic cancer cell lines Patu8988 and Panc1, rottlerin treatment inhibits tumor cell proliferation, migration and invasion, which is due to downregulated Skp2 expression at mRNA and protein levels (Su et al., 2016a; Yin et al., 2016).