To provide siRNAs to tumor M2-TAMs and BC cells that target vascular endothelial growth factor (VEGF) and placental growth factor (PIGF), Song et al. developed a polymeric nanoparticle based on PEG- and mannose-doubly modified trimethyl chitosan and citraconic anhydride grafted poly (allylamine hydrochloride) (Song et al., 2018). This evidence concerns the gene VEGFA and neoplasm.