In a rat DN model induced by STZ, AS-IV (40 mg/kg, for 8 weeks) also downregulated miR-192 expression and reduced the mRNA and protein levels of TGF-β1, Smad3, α-SMA, and COL-1, while increasing the mRNA and protein expression of Smad7. The gene discussed is ACTA1; the disease is liver dysplastic nodule.