AR treatment (2.1 g/kg for 12 weeks) in STZ-induced DN rats can reduce 24-hour urine protein quantification, attenuate interstitial pathological damage, and inhibit the expression of wnt4, β-catenin, and TGF-β1 in the renal interstitium, thus playing a role in kidney protection and slowing down the process of interstitial fibrosis in DN rats (Deng and Fang, 2012). This evidence concerns the gene WNT4 and liver dysplastic nodule.