PTPN1 and Insulin resistance: Sheng-Li Niu(Niu et al., 2020) identified this new geranylated flavonoid and its structural analogues by wave spectroscopy, and by studying its modulation of protein phosphatase 1B (PTP1B) D The new flavonoid was found to increase glucose consumption by cells with insulin resistance, as well as on glucose consumption by HepG2.