GSK3B and Alzheimer disease: Banqiao Badix Codonopsis Polysaccharide (BCP) could effectively improve cognitive dysfunction induced by elevated GSK-3β activity in rats, and the possible mechanism was related to the downregulation of GSK-3β activity, which in turn inhibited Tau protein hyperphosphorylation and promoted neuronal development, and had some preventive or delaying effects on AD (Luo et al., 2017).