MAPK8 and Nephropathy: GSF can also regulate and inhibit changes in the cytoskeleton, reduce the migration of glial cells, improve vascular endothelial function (Bance et al., 2019; Natale et al., 2019), inhibit processes that damage podocytes, protect nephrons, and improve the symptoms of kidney damage in the M2 community by interfering with VEGFA, PRKCB, and JNK in the focal adhesion pathway.