The top 20 pathways included pathways in cancer, the AGE-RAGE signaling pathway in diabetic complications, the IL-17 signaling pathway, the NF-kappa B signaling pathway, lipid and atherosclerosis, the TNF signaling pathway, the MAPK signaling pathway, hepatitis B, the toll-like receptor signaling pathway, prostate cancer, the HIF-1 signaling pathway, the PI3K-Akt signaling pathway, microRNAs in cancer, apoptosis, fluid shear stress and atherosclerosis, chagas disease, the VEGF signaling pathway, human cytomegalovirus infection, the FoxO signaling pathway, and osteoclast differentiation. This evidence concerns the gene TNF and Familial prostate cancer.