TNF and Herpesviridae infectious disease: Moreover, a total of 139 signaling pathways were yielded through KEGG enrichment analysis, including Bladder cancer, Lipid and atherosclerosis, Kaposi sarcoma-associated herpesvirus infection, AGE-RAGE signaling pathway, IL-17 signaling pathway, Hepatitis C, Human cytomegalovirus infection, Estrogen signaling pathway, Breast cancer, and TNF signaling pathway.