HE training lead to a decrease of IFN-γ and IL-17 and an increase of IL-10 and TGF-β. Analysis of CD4 + T cell subsets from CNS of EAE showed the reduction of Th1 and Th17 populations and an increase of Treg in HE, not ME mice. This evidence concerns the gene TGFB1 and hereditary elliptocytosis.