In the mucosa-associated microbiota of the FW group, UCG-009, Clostridia_UCG-014, Candidatus Saccharimonas, Butyrivibrio, Ruminococcus, and Monoglobus were significantly negatively related with il10 and tgfβ1. Candidatus Saccharimonas is associated with human diseases such as IBD and gingivitis etc. (dos Santos Cruz et al., 2020). This evidence concerns the gene TGFB1 and gingivitis.