Nevertheless, this does not exclude the possibility that upregulation of this, and other pathways leading to increased net positive surface charge, also contribute to the CHD susceptibility profile in some strains of P. mirabilis, and that inactivation of relevant pathways in the RS47-2 mutant may further reduce CHD MIC (Wang et al., 2008; Jiang et al., 2010). Here, CHDH is linked to coronary artery disorder.