Meanwhile, current studies have shown that inflammatory factors such as IL-6, IL-10, IL-1β, and estrogen play an important role in the occurrence of ccRCC (Negrier et al., 2004; Petrella and Vincenti, 2012; Cuadros et al., 2014; Quan et al., 2017). This evidence concerns the gene IL6 and nonpapillary renal cell carcinoma.