In parallel, the proportion of CD8+IFNγ+ T lymphocytes from tumor tissue in H22-MP-loaded monocytes group was obviously higher than that in the monocytes alone and PBS control group (Fig. 8b), suggesting that transplantation of monocytes alone may not lead to adequately activate T lymphocytes, possibly due to the fact that monocytes did not undergo reprogramming by T-MPs. The gene discussed is IFNG; the disease is neoplasm.