TGFB1 and atherosclerosis: Moreover, we believed that SERPINF1, which is mainly expressed in fibroblasts and fibromyocytes, regulated atherosclerosis through participating in Jak-STAT signaling pathway, Wnt signaling pathway, and TGF-β signaling pathway (Supplementary Figure S4E), which were the crucial mechanisms for plaque formation and rupture mediated by multiple cell types.