Among them, the Jak-STAT signaling pathway is significantly enriched in fibroblasts expressing SERPINF1. Moreover, some common cardiovascular diseases were enriched in cells with low expression of SERPINF1, such as arrhythmogenic right ventricular cardiomyopathy (ARVC), dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM) (Figure 6D). The gene discussed is SOAT1; the disease is arrhythmogenic right ventricular cardiomyopathy.