Several reports had proved that JAK/STAT signal transduction contributed to the expression of inflammatory genes (Ortiz-Muñoz et al., 2009; Qin et al., 2014), the apoptosis of macrophages (Lim et al., 2008), and the phenotypic activation of endothelial cells (Qin et al., 2014) in atherosclerosis. Here, SOAT1 is linked to atherosclerosis.