Increase in TMAO has been demonstrated to aggravate Angiotensin II-induced hypertension by inducing constriction of afferent arterioles and mesenteric arteries and mediating acute pressor response through the PERK/ROS/CaMKII/PLCβ3/Ca2+ signalling pathway in mouse (Jiang et al., 2021). The gene discussed is AGT; the disease is hypertensive disorder.