Among the mechanisms that contribute to dysbiosis-mediated high blood pressure include stimulation of hormonal secretion such as dopamine, serotonin and norepinephrine (Kang and Cai, 2018), and activation of the SCFA olfactory receptor 78 (Olfr78) expressed in the glomerular afferent arterioles and smooth muscle cells of arterial walls eliciting vasoconstriction activities partly through renin production resulting in increased blood pressure (Tang et al., 2017; Canale et al., 2021). This evidence concerns the gene REN and hypertensive disorder.