The functional role of Gβγ proteins in the regulation of respiratory depression by opioid drugs suggests that Gβγ proteins may serve as molecular targets to develop therapies that could reverse respiratory depression following opioid overdose, especially in the context of highly potent fentanyl analogs for which the opioid overdose antidote naloxone is not effective (Pergolizzi, 2021). The gene discussed is CFB; the disease is Respiratory insufficiency due to muscle weakness.