Falcao et al., sought to investigate the occurrence of preeclampsia-like features in a hypertensive mouse model during pregnancy using double transgenic mice that overexpress the genes for human renin (REN, R+) and human angiotensinogen (AGT, A+) (R+A+ mice) (Sigmund et al., 1992; Falcao et al., 2009). This evidence concerns the gene REN and preeclampsia.