HIF1A and preeclampsia: The use of advanced techniques in combination with preexisting comorbidity models, such as trophoblast-specific gene transfer of HIF-1α in mice on a high fat Western diet or sFLT1 in non-obese diabetic mice, may more accurately reflect preeclampsia superimposed on a comorbidity (Kaufman et al., 2014; Albers et al., 2019; Vaughan et al., 2021).