Several groups have investigated the effect of eNOS knockout on blood pressure and the generation of preeclampsia-like symptoms in mice, following reports that chronic non-specific pharmacologic inhibition of NOS recapitulates some symptoms of preeclampsia (Baylis & Engels, 1992; Yallampalli & Garfield, 1993; Shesely et al., 1996; Hefler et al., 2001; Shesely et al., 2001; Kusinski et al., 2012). The gene discussed is NOS1; the disease is preeclampsia.