In patients with preeclampsia; however, the maternal levels of plasma renin, angiotensin II, and aldosterone have been shown to be lower than normotensive pregnancies (Weir et al., 1973; Gant et al., 1980; Brown et al., 1997; Irani and Xia, 2008; Leaños-Miranda et al., 2018). This evidence concerns the gene REN and preeclampsia.