REN and preeclampsia: Both models show that the excess secretion of renin and other renin-angiotensin-aldosterone system proteins or angiotensin-like peptides by the placenta can lead to the development of preeclampsia-like symptoms during mouse pregnancy (Takimoto et al., 1996; Shah et al., 2000; Falcao et al., 2009; Denney et al., 2017).