We used LASSO Cox regression to examine data from the TCGA dataset to identify a 20-gene signature (ADAMTS2, ADAMTS4, ADAMTS8, COL15A1, COL4A4, COL4A6, DCN, GPC2, HMCN1, ITGA5, ITGAX, MEGF6, MMP21, MMP7, NELL1, NPNT, PXDN, SEMA3B, VCAN, and VWA1) in ccRCC patients. Here, VWA1 is linked to nonpapillary renal cell carcinoma.