We used LASSO Cox regression to examine data from the TCGA dataset to identify a 20-gene signature (ADAMTS2, ADAMTS4, ADAMTS8, COL15A1, COL4A4, COL4A6, DCN, GPC2, HMCN1, ITGA5, ITGAX, MEGF6, MMP21, MMP7, NELL1, NPNT, PXDN, SEMA3B, VCAN, and VWA1) in ccRCC patients. The gene discussed is HMCN1; the disease is nonpapillary renal cell carcinoma.