CD4 and infection: An epidemic of mpox was labeled a Public Health Emergency of International Concern by the WHO on July 23, 2022.3,26,27,62,63 Even though evidence is just starting to emerge, it is possible that mpox can present with more severe symptoms in immunocompromised adults than in the general population.64,65 The CDC found that among 57 patients hospitalized with severe mpox infection between August and October 2022, 90% had underlying immunocompromising diseases, including 31 people with HIV who had a CD4 cell count of fewer than 50 cells/mm.