CDK4 and neoplasm: In tumor tissues, seven gene amplification mutations included CDK4 (Mutation abundance, MA:1.57), AKT2 (MA:1.65), CCND2 (MA:1.63), MDM2 (MA:1.57), NTRK1 (MA:2.38), AXL (MA:1.65), and KRAS (MA:1.63), as well as the AFF3 gene missense (c.1781_1787del insC).