The absolute number of CD4+T cells is decreased in the inflamed liver and NAFLD-promoted HCC.20,26 A study suggested that selective loss of CD4+T lymphocytes in NAFLD promotes hepatocarcinogenesis.27 It is also reported that CD4+T cells inhibit the initiation of HCC and contribute to tumor regression.28,29. This evidence concerns the gene CD4 and hepatocellular carcinoma.