Based on extensive studies, it is proposed that TAM in TME is mostly polarized to anti‐inflammatory macrophages (M2 phenotype), which have the potential to elevate the activity of IL‐10, TGF‐β, and hyperarginase‐1, and stimulate the expression of cell surface markers, in addition to promoting tumor angiogenesis, growth, and expression of various immunosuppressive cytokines.66 Here, IL10 is linked to neoplasm.