Ma et al. showed that the combined transcriptional profiling of Oct4/Sox2 co‐expressing GSC and differentiated GBM cells identified a microenvironment consisting of an immunosuppressive transcriptome composed of multiple immunosuppressive checkpoints (i.e., PD‐L1, CD70, A2aR, and TDO) synergistically induced by Oct4 and Sox2 and dysregulation of immunosuppressive tumor‐associated cytokines and chemokines. The gene discussed is SOX2; the disease is glioblastoma.