Clinically, in Caucasian populations, CRSwNP with asthma is characterized by tissue eosinophilia and high local IgE levels [4] Increasing severity of asthma is associated with greater prevalence and severity of CRSwNP [5, 6] while the multimorbidity of CRSwNP and asthma is associated with more severe sinonasal symptoms and worse quality of life [4]. This evidence concerns the gene IGHE and chronic rhinosinusitis with nasal polyps.