To simulate the clinical practice, we next tested the therapeutic potential of circTmeff1 inhibition in another model of established muscle atrophy, which is immobilization‐induced muscle atrophy (SWI, spiral wire immobilization model).[25] Eight‐week‐old mice were subjected to SWI, and the muscle atrophy was occurred after 3 days as indicated by the increased expressions of Atrogin‐1, MuRF‐1 and circTmeff1 (Figure S12A, Supporting Information). This evidence concerns the gene TRIM63 and Atrophy.