TARDBP and amyotrophic lateral sclerosis: Our result is consistent with previous results that cytoplasmic TDP‐43 in mice dramatically decreased tibialis anterior and gastrocnemius muscle mass.[38] Also, phosphorylated TDP‐43 was observed to be aggregated in skeletal muscle of patients with ALS.[39] In contrary, other work has shown that TDP‐43 is increased in damaged muscle and elevated regeneration.