Tumor necrosis factor alpha is the important mediator of muscle atrophy in cancer cachexia or inflammation.[33] Specially, as a noninvasive atrophy model, SWI‐induced muscle atrophy model is more suitable for therapeutic evaluation mainly due to its inability to cause local irreversible injury in mice.[33c] Depend on the result from these different models, circTmeff1 maybe a biomarker for muscle atrophy disease. This evidence concerns the gene TNF and cancer.