The incidence of TDP‐43‐dependent cell death depends on triggering mitochondrial DNA (mtDNA) release into the cytoplasm, which subsequently activates the cytoplasmic DNA‐sensing cyclic GMP‐AMP synthase (cGAS)/stimulator of interferon genes (STING) pathway in ALS, acute kidney injury, acute liver injury and diabetic cardiomyopathy.[28] Using qRT‐PCR, the release of mtDNA in cytosol was analyzed by mtCOI, and it was found that circTmeff1 promoted mtDNA accumulation in the cytosol in myotube cell and mice (Figure 7I). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.