The results indicated that, consistent with the results of TCGA analysis, the expression of IGFBP2 (P < 0.001) and IGFBP6 (P = 0.005) in gastric cancer tissues was lower than that in normal gastric tissues; the expression of IGFBP6 (P < 0.001) in colorectal cancer tissues was also lower than that in normal colorectal tissues (Fig. 14). Here, IGFBP2 is linked to colorectal cancer.