However, previous research on the relationship between IGFBPs and human tumors usually focused on a single gene in the most common cancers, such as breast cancer, lung cancer, and gastric cancer, etc. The family member IGFBP4, IGFBP5, IGFBPL1 has been less studied in relation to cancer compared with other members. The gene discussed is IGFBP4; the disease is gastric cancer.