Therefore, we designed a multiparametric flow cytometry panel to concomitantly assess cell death modes (apoptosis, necroptosis, and parthanatos) and stress responses (DNA damage response, proliferation, cell cycle, autophagy, and endoplasmic reticulum [ER] stress response) utilizing dimension reduction and unsupervised clustering to gain a broad overview of the treatment-specific proteomic landscape and assess whether VEN, AMG176, or co-treatment elicited overlapping or distinct proteomic shifts across leukemia cells with different TP53 statuses. This evidence concerns the gene TP53 and leukemia.