To assess whether TP53 status alters cell death patterns and stress responses in an unsupervised manner, we quantified the fractions of leukemia cell subpopulations with different TP53 backgrounds treated with VEN, AMG176, or both (Fig. 4D) and performed clustering analysis using the frequencies of subpopulations detected across the overall leukemia landscape to delineate the direction of the treatment response and identify the similarity of cluster composition and thus response patterns among the isogenic cells with different TP53 statuses. Here, TP53 is linked to leukemia.