This effect inhibits the priming of naïve T cells in lymphoid organs.[27] When mDCs initiate T‐cell activation, the surface molecule programmed death‐ligand 1 (PD‐L1)/PD‐L2 on tumor cells engages the PD‐1 receptor on T cells, which suppresses the cytokine production, expansion, and cytolytic function of T cells. This evidence concerns the gene CD274 and neoplasm.