Several lipid classes, such as free fatty acids (FFAs), diacylglycerol (DAG), and ceramides, are known to mediate insulin resistance in the liver.[11] To determine if loss of Lpcat3 affects the levels of these lipids, we performed a shotgun lipidomic analysis in both chow and HFD‐fed mouse livers. Here, LPCAT3 is linked to Insulin resistance.