INS and Insulin resistance: Prostaglandin E2 (PGE2), a product of arachidonic acid metabolism, has been shown to contribute to insulin resistance.[12] The levels of PGE2 were comparable between control and LKO mice on chow or HFD (Figure S3H, Supporting Information), suggesting that PGE2 is unlikely to be involved in the regulation of insulin signaling in the absence of Lpcat3.