INS and Insulin resistance: Our previous observation that Lpcat3 expression is increased in ob/ob mouse liver promoted us to hypothesize that LPCAT3 and PL remodeling may be involved in the pathogenesis of insulin resistance.[10b] In support of this hypothesis, insulin treatment indeed significantly increased mRNA levels of Lpcat3 in Hepa 1–6 cells (Figure1A), which was comparable to the induction of known downstream genes of insulin, Srebf‐1c and Fasn.