Mass spectrometry analysis revealed that polyunsaturated PCs, especially arachidonoyl‐containing PCs, were dramatically elevated, while saturated and monosaturated PCs were decreased in HFD‐fed livers (Figure 1C), suggesting that hyperinsulinemia in both genetic‐ and diet‐induced mouse models enhances Lpcat3 expression and membrane PL unsaturation in the liver. This evidence concerns the gene LPCAT3 and Hyperinsulinemia.