TIMP1 and Hepatic fibrosis: Since MMP is an essential enzyme in degradation of collagen, the highly expressed TIMP‐1 is considered as another central mechanism for inducing liver fibrosis.[9] Therefore, simultaneously regulating P4H and TIMP‐1 in aHSC may be a potential strategy to disturb the imbalance between collagen deposition and degradation for reversal of liver fibrosis.