In our study of the interacting proteins and downstream signaling molecules of BEST1, we observed that BEST1 expression activates AKT signaling to promote IL‐6 and IL‐8 production, which is consistent with several other studies.[50, 51, 52] However, the specific mechanism needs to be further studied, which do not exclude the possibility that BEST1 promotes tumor cell proliferation beyond cytokines. This evidence concerns the gene IL6 and neoplasm.