Human monocytes can be subdivided into three subsets according to the expression of CD14 and CD16, that is, classical (CD14++CD16−), intermediate (CD14++CD16+), and nonclassical (CD14+CD16++).[19] We found that BEST1 was expressed in all three subsets, and the expression level was significantly elevated on classical, but not intermediate or nonclassical monocytes from patients with HNSCC compared with those of healthy donors via flowcytometry (Figure S1b, Supporting Information and Figure 1e). Here, FCGR3A is linked to head and neck squamous cell carcinoma.