SIGLEC1 and neoplasm: This crosstalk might result in two aspects: first, promoting tumor cell proliferation or metastasis by TIM through the production of cytokines such as interleukin‐6 (IL‐6) and IL‐8;[5, 6] second, modifying transcriptional landscape of TIM by tumor such as the specific expression of genes SIGLEC1 or STING1, which reflect the prognosis of patients to a certain extent.[7, 8] In terms of shaping TIM, whether the impress of crosstalk on TIM can be detected in places other than tumor has not been disclosed since evidence of monocytes circulating back to the blood is few.