Besides playing an important role in the chemotaxis of tumor‐infiltrated monocytes, VEGF‐A stimulates autophosphorylation and downstream signal transduction of VEGFR‐1 and VEGFR‐2 in monocytes.[26, 43, 44] Once VEGFR is activated, MAPK pathway is activated to regulate BEST1 gene expression, as well as IP3 induction to facilitate endoplasmic reticulum calcium store release. This evidence concerns the gene VEGFA and neoplasm.