Notably, several other NRF2 target genes, such as HMOX1 and NQO1, which are associated with antioxidant activity and ferroptosis [43], were also downregulated in UTP11-deficient cancer cells (Fig. 6K, L, and 6 N; Supplementary Figs. 5S and 5U). The gene discussed is HMOX1; the disease is cancer.