Treatment with the potent but promiscuous TXNRD1 inhibitor, auranofin, in a hemochromatosis mouse model showed an increase in hepatic malondialdehyde (MDA), a product of lipid peroxidation, and Ptgs2 mRNA levels, which is highly associated with ferroptosis [37]. This evidence concerns the gene PTGS2 and hemochromatosis type 1.