In the three major renal cell carcinoma (RCC) subtypes, i.e., clear cell renal cell carcinoma (ccRCC), a renal malignancy associated with metastasis and high lethality [73], as well as in papillary renal carcinoma (pRCC) and chromophobe renal carcinoma (chRCC), two non-clear-cell renal carcinoma types with a more favorable outcome [74], TMIGD1 expression is reduced [16, 19, 20]. The gene discussed is TMIGD1; the disease is renal cell carcinoma.