In summary, the frequent and highly significant loss of TMIGD1 expression in CRC tissue, its gradual downregulation during progression from non-polypoid to polypoid to CRC lesions, its role in limiting cell proliferation, and finally its protective function in tumor development and metastasis formation in mice, strongly support a tumor-suppressive function of TMIGD1. This evidence concerns the gene TMIGD1 and colorectal carcinoma.