A DNA methylation analysis based on human disease methylation database (DiseaseMeth version 2.0) [81] revealed that the TMIGD1 gene is in fact methlyated in colonic and rectal carcinoma [68], suggesting that methylation of the TMIGD1 promoter contributes to the silencing of the TMIGD1 gene during development of colon carcinoma. This evidence concerns the gene TMIGD1 and rectal carcinoma.