The tumor-suppressive activity of ectopic TMIGD1 expression in renal cancer cell lines is associated with activation of p38α, phosphorylation of p53, and upregulation of two CDK inhibitors, CDK inhibitor 1 A (p21CIP1) and CDK inhibitor 1B (p27KIP1) [20], which strongly suggests that the tumor-suppressive activity of TMIGD1 is based on its ability to activate the p38 MAPK signaling pathway. Here, TMIGD1 is linked to renal carcinoma.