Notably, anti-ICAM-1 antibody combined with RV-A16 infection, but not anti-ICAM-1 antibody alone, decreased expression of RV-induced ICAM-1, and other antiviral and inflammasome related molecules, namely IFNB (IFN-β), IFNL (IFN-λ), IFIH1 (MDA5), DDX58 (RIG-I), IL1B (IL-1β), CASP1 (caspase-1) and GSDMD (gasdermin D) (Supplementary Fig. 3k). The gene discussed is RIGI; the disease is infection.