In summary, we found here that SARS-CoV-2 infection alone did not induce DDX58 (RIG-I), IFIH1 (MDA5), IFNB (IFN-β), IFNL1 (IFN-λ1) or IL1B (IL-1β) at 48 h after infection, but induced IL-33, IL-18, and decreased CCL4 secretion, suggesting its early proinflammatory inflammasome-inducing and delaying antiviral capacity in asthma. Here, IFNL1 is linked to asthma.