Knowing that house dust mite (HDM) exposure combined with rhinovirus infection have an especially detrimental impact on severity of asthma exacerbations in children and adults6,19, we investigated the effect of HDM on rhinovirus-induced RIG-I inflammasome activation in bronchial epithelium in a dose, time and source-dependent manner in vitro (Supplementary Fig. 5a–c). Here, RIGI is linked to asthma.