In contrast, in undifferentiated, submerged cultures of primary human airway epithelial cells infection with IAV revealed RIG-I and NLRP3-inflammasome-dependent mature IL-1β release36, while infection with RV in a similar model led to activation of NLRP3/NLRC5/ASC complexes and mature IL-1β release53. The gene discussed is NLRC5; the disease is infection.