In the current study we demonstrated in vivo and in vitro that recognition of replicating RV by RIG-I helicase in bronchial epithelial cells of patients with asthma led to the augmented ASC recruitment, oligomerization, activation of caspase-1, processing and release of mature IL-1β via formation of RIG-I inflammasome, independently of NLRP3 or MDA5. The gene discussed is IL1B; the disease is asthma.