Importantly, HDM pre-stimulation significantly increased the release of GM-CSF, IL-33, VEGFA, EGF, TWEAK, IL-7, MMP12, FTL3G, M-CSF, MMP1, G-CSF in double infected epithelium of patients with asthma, whereas it decreased secretion of TGFA, TNF, TWEAK, CCL7 and CCL11 in healthy controls (Fig. 6g, i). Here, TNFSF12 is linked to asthma.