Here, we found that HDM contributes significantly to RV-induced pathologic responses in human airway epithelium in patients with asthma by (i) enhancement of non-mature pro-IL-1β expression and release, (ii) overactivation of RIG-I inflammasome and subsequent release of mature caspase-1, mature IL-1β, and RIG-I, (iii) inhibition of type I/III IFNs and ISG-responses and (iv) activation of extra proinflammatory and pro-remodeling proteins, such as IL-1α, SLAMF163, CD4064 and TRANCE (RANKL)67. Here, TNFSF11 is linked to asthma.