Having identified IRE1α as a target gene of p52 and ETS1 cooperativity, we proceeded to validate its functional roles in glioma progression by performing short hairpin RNA (shRNA)-mediated KD of the gene in U-87 MG and U-251 MG cell lines (Fig. 5a, Supplementary Fig. 8). This evidence concerns the gene NFKB2 and glioma.