In contrast, HIS T cells incubated with Raji cells and anti-CD3/CD28 exhibited a strong IFNγ ELISpot response, and this effect was specific for Raji cells since Ramos cells, A20 cells, (a murine lymphoma), and HEK293 cells, (human epithelial cells), did not recapitulate this “helper” function of Raji cells towards T-cell activation (Supplementary Fig. 3). The gene discussed is CD28; the disease is lymphoma.