MAGEA4 and cancer: Only one of 15 evaluable patients had a deep response in the phase 1 SURPASS trial that evaluated ADP-A2M4CD8 SPEAR T-cells co-expressing the CD8α co-receptor with the engineered TCR targeting MAGE-A4 in HLA-A*02-positive patients with advanced cancers expressing MAGE-A4 antigen [15].