PSMB8 and Erythema: Autosomal recessive loss-of-function (LOF) mutations in the proteasome subunit beta type 8 (PSMB8) cause Nakajo-Nishimura syndrome (NNS) with nodular erythema, elongated and thickened fingers, and emaciation [1, 3, 4], and CANDLE [1, 4, 5].