For example, in a post hoc analysis of data from three clinical trials, among patients with moderate-to-severe RA, those who achieved sustained Boolean or Clinical Disease Activity Index remission or DAS28 (CRP) < 2.6 and/or “deep remission” (DAS28 [CRP] ≤ 1.98) were more likely to maintain remission/LDA after etanercept dose reduction/withdrawal than patients who only achieved remission or LDA [37]. The gene discussed is CRP; the disease is rheumatoid arthritis.